Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3111 | 3111-30515 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82S | L24I, L33F | L10I, I13V, M36I, N37D, R57K, I62V, L63P, I64V, A71V |
| >3111-30515| codons 4-99 TLWQRPIVTVKIGGQLKEALIDTGADDTVFEEIDLPGRWKPKIIGGIGGFVKVKQYDQVP VEICGHKVIGTVVVGPTPSNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_QA, L210W, T215Y | A62V, D67E | Y181C | K43E, S68G, V118I, K122E, E138Q, R211N, E224D, L228H |
| >3111-30515| codons 38-247 CTELEEEGKISKIGPENPYNTPVFVIKKKEGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLWNWGFYTP DKKHQKDPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |