Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3204 | 3204-30821 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | K43E, T69TN, A98S, V118I, K122E, G196E, T200A, E203K, Q207E, R211K, L228H |
| >3204-30821| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHP SGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82L, L90M | V11I, L33F, K43T, G73S | L10I, I13V, K14E, I15V, K20R, E35D, M36I, N37E, R41K, D60E, Q61E, I62V, L63P, A71V, I72R, I85V, I93L |
| >3204-30821| codons 4-99 TLWQRPIITVEVGGQLREALLDTGADDTVFEDIELPGKWTPKMIGGIGGFLKVRQYEEVP IEICGHKVRSTVLVGPTPLNIVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |