<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3204 3204-30821 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, V82L, L90M V11I, L33F, K43T, G73S L10I, I13V, K14E, I15V, K20R, E35D, M36I, N37E, R41K, D60E, Q61E, I62V, L63P, A71V, I72R, I85V, I93L  
>3204-30821| codons 4-99
TLWQRPIITVEVGGQLREALLDTGADDTVFEDIELPGKWTPKMIGGIGGFLKVRQYEEVP
IEICGHKVRSTVLVGPTPLNIVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y K219N L100I, K103N   K43E, T69TN, A98S, V118I, K122E, G196E, T200A, E203K, Q207E, R211K, L228H  
>3204-30821| codons 38-247
CTELEEEGKISKIGPENPYNTPVFAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHP
SGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRAKIKELREHLWKWGFYTP
DNKHQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006