Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3203 | 3203-31229 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 20 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54AV, V82VA | K43KT | L10I, K20R, E35D, M36I, Q61QR, L63P, A71V |
| >3203-31229| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTILEDINLPGRWTPKIVGGIGGFVKVRQYDRIP IEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, M184I, L210W, T215Y | K219E | K103N | K64KR, V90VI, K102Q, V118I, K122E, D123E, S162Y, D177G, T200A, H208HY, L228H, Q242QH |
| >3203-31229| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIRKKNSTRWRKIVDFRELNKRTQDFWEIQLGIPHP AGLKQNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPGIVIYQYIDDLYVGSDLEIGQHRAKIEELRQYLWRWGFYTP DEKHQKEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |