<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-3157 3157-30515 Canada 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74I, M184V, L210LW, T215F V75T, K219Q K103N, Y181C V108I, E138EK T39A, K122E, D123DN, I135T, S162A, E169D, G196E, T200TAEK, K201KI, I202V, D218E, L228LH, V245K  
>3157-30515| codons 38-247
CAELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTILDVGDAYFSVPLDENFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSP
AIFQASMTKILDPFRKQNPDIVICQYVDDLYVGSDLEIEQHRKIVEELRQHLWRWGFFTP
EQKHQKEPPFHWMGYELHPDKWTVQPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46IL, I54V, I84V, L90M G73S, L89V L10I, V11L, K14KR, I15V, K20V, M36MI, R41RK, D60E, I62V, L63P, A71V, I72L, P79A, I85V  
>3157-30515| codons 4-99
TLWQRPILTIRVGGQLVEALLDTGADDTVLEEINLPGKWKPKLIGGIGGFVKVRQYEQVP
IEICGHKVLSTVLVGATPVNVVGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006