Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3157 | 3157-30515 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54V, I84V, L90M | G73S, L89V | L10I, V11L, K14KR, I15V, K20V, M36MI, R41RK, D60E, I62V, L63P, A71V, I72L, P79A, I85V |
| >3157-30515| codons 4-99 TLWQRPILTIRVGGQLVEALLDTGADDTVLEEINLPGKWKPKLIGGIGGFVKVRQYEQVP IEICGHKVLSTVLVGATPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, V75T, M184V, L210LW, T215F | K219Q | K103N, Y181C | V108I, E138EK | T39A, K122E, D123DN, I135T, S162A, E169D, G196E, T200TAEK, K201KI, I202V, D218E, L228LH, V245K |
| >3157-30515| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDENFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSP AIFQASMTKILDPFRKQNPDIVICQYVDDLYVGSDLEIEQHRKIVEELRQHLWRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |