Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3119 | 3119-40623 | Canada | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82T, L90M | V11I, L33I, N88D | I15V, K20V, E35G, M36I, R41K, I62V, L63P, I66L, A71T, I72M, I85V, F99Y |
| >3119-40623| codons 1-99 PQITLWQRPLITIKVGGQLVEALLDTGADDTVIEGINLPGKWKPKLIGGIGGFVKVRQYD QVPIELCGHKTMGTVLVGPTPTNIVGRDLMTQIGCTLNY |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | F77FL | V35K, T39A, K43A, E44D, K101Q, V118I, K122E, D123E, I135T, S162N, R211K, V245E, K277R, I293V, E297R, A360T, K366R, A371V |
| >3119-40623| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICAELEADGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |