Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3119 | 3119-30710 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 12 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75M, F77L | V35VEIK, T39A, K43KEQ, K49KR, K101Q, V118VI, K122E, D123E, I135T, R211K, V245E, K277R, I293V, E297R, A360T, K366R, A371V, A376T, K390R, A400T |
| >3119-30710| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICAELEQEGKISRIGPENPYNTPV FAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLTEVVQKITTESIVIWGKTPKFRLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33I, N88D | L10I, I15V, L19LV, K20IM, E35EG, M36I, R41K, K45KR, I62V, L63P, A71T, I72IM, I85V |
| >3119-30710| codons 1-99 PQITLWQRPIVTIKVGGQVMEALLDTGADDTVIEGINLPGKWKPRLIGGIGGFVKVRQYD QVPIEICGHKTMGTVLVGPTPANIVGRDLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |