Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3058 | 3058-30409 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, V82A, I84V | L10F, L24I, L33F | R41K, D60E, I62V, L63P, I64V, I72V, L89LF |
| >3058-30409| codons 4-99 TLWQRPFVTIKIGGQLKEALIDTGADDTVFEEMNLPGKWKPKIIGGIGGFVKVRQYEQVP VEICGHKAVGTVLVGPTPANVIGRNFLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, T215Y | V60I, K122E, G196E, T200IV, E203ED, H235HL |
| >3058-30409| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRVKIDELRQHLLRWGFYTP DKKHQKEPPFLWMGYELLPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |