Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3053 | 3053-30402 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82A, L90M | L10I, I13V, K20I, L33L_L, E35D, M36I, N37D, I62V, L63P, A71V, L89I |
| >3053-30402| codons 4-99 TLWQRPIVTVKIGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFAKVRQYDQVP IEICGHKVIGTVLVGPTPANIIGRNIMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | K101P, K103N | E44D, V60VI, A98S, V106I, V118I, K122E, I135IM, V179I, I202V, H208HY, R211K, L228LH |
| >3053-30402| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLPKNKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYMDDLYVGSDLEIGQHRTKVEELRQYLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |