Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2193 | 2193-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A, L90M | L10I, G16A, I62V, L63P, A71V, I72V, V77I, I93L |
| >2193-30821| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGVGGFAKVRQYDQVP IEICGHKVVGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219R | K103KN, Y181C | E40Q, K43E, E44A, V111I, S117A, K122E, S162SN, S163T, M164MI, K166KN, V179I, G196E, Q197K, H208Y, R211K, H221Y, L228H, V245E |
| >2193-30821| codons 38-247 CTQLEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDIGDAYFAVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNTITNILEPFRKQNPDIIICQYVDDLYVGSDLEIEKHRTKIEELRQYLWKWGFYTP DRKYQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |