<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2193 2193-30821 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54A, V82A, L90M   L10I, G16A, I62V, L63P, A71V, I72V, V77I, I93L  
>2193-30821| codons 4-99
TLWQRPIVTIKIAGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGVGGFAKVRQYDQVP
IEICGHKVVGTVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219R K103KN, Y181C   E40Q, K43E, E44A, V111I, S117A, K122E, S162SN, S163T, M164MI, K166KN, V179I, G196E, Q197K, H208Y, R211K, H221Y, L228H, V245E  
>2193-30821| codons 38-247
CTQLEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTVLDIGDAYFAVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQNTITNILEPFRKQNPDIIICQYVDDLYVGSDLEIEKHRTKIEELRQYLWKWGFYTP
DRKYQKEPPFHWMGYELHPDKWTVQPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006