Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1594 | CA7449 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 191 |
| 2 | AZT+DDC | 121 |
| 3 | 3TC+AZT+SQV | 39 |
| 4 | 3TC+AZT+IDV | 21 |
| 5 | 3TC+D4T+RTV | 21 |
| 6 | 3TC+D4T+NFV+NVP | 17 |
| 7 | 3TC+AZT+RTV+SQV | 34 |
| 8 | DDI+EFV | 21 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184MV, T215F | K219Q | K103N, Y188L | P4S, K32KQ, T39A, K43E, V60I, T69N, R83K, V90I, I135M, T139S, S162Y, D177E, I178M, G196E, Q197E, T200A, L228H | L187M |
| >CA7449| codons 1-258 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIQALVEICAELEEEGKISKIGPENPYNTPI FAIKKKNSNRWRKLMDFRELNKKTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSMNNESPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEMVI YQYVDDMLVGSDLEIEEHRAKIEELRQHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GV, I54V, V82A, L90M | L10I, N37S, R41K, L63P, A71V, V77VI, I93L |
| >CA7450| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIVGIGGFVKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |