Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1733 | 1733-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L33F, G73T | L10I, I13V, K55R, I62V, L63P, C67F, A71T, I72T, V77I, P79A, I93L, C95V, F99Y |
| >1733-30424| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFMRVRQYDQVP IEIFGHKTTTTVLIGATPVNVIGRNLMTQLGVTLNY |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | K103N, Y181I | T69N, K101Q, V118VI, K122E, D123N, I135T, S162D, I178M, V179I, T200A, F214L, D218E, L228H, V245K |
| >1733-30424| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDMIIIQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |