Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1262 | 1262-30324 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184MV, L210W, T215Y | K70Q | Y188L | T39A, K43E, V60I, V118I, I135IV, T139TA, S162SC, V189VI, E203D, H208HY, R211K, H221Y, V245T | E40FS, K103M |
| >1262-30324| codons 38-247 CASLEEEGKISKIGPENPYNTPIFAIKKKNSDQWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKMKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLLIGSDLEIGQHRTKIDELRQYLWKWGFYTP DKKYQKEPPFLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82C, L90M | K43T, L89V | L10I, V11L, I15V, L19LQ, K20I, E35D, M36I, N37ND, R41K, L63P, A71V, I85V, Q92K |
| >1262-30324| codons 4-99 TLWQRPILTIKVGGQQIEALLDTGADDTILEDIDLPGKWTPKIVGGIGGFLKVRQYDQIP IEICGHKVIGTVLVGPTPCNIVGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |