Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2342 | 2342-30730 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90LM | L10F, L33F, T74P | I13V, I15V, G16E, L19I, K20T, E35G, M36I, P39T, R41RK, R57K, I62V, L63C, A71V, I72T, I93L |
| >2342-30730| codons 4-99 TLWQRPFVTVKVEGQITEALLDTGADDTVFEGINLTGKWKPKIIGGIGGFVKVKQYDQVC IEICGHKVTGPVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219E | K103N, Y181YC, G190GA | V108VI | K104KR, D121H, K122E, I135V, K166KR, I167IV, D177DE, I178IV, E194ED, T200TA, I202IV, D218E, L228H, V245M |
| >2342-30730| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNRSVTILDVGDAYFSVPLHEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRVLEPFRKQNPEVVICQYVDDLYVASDLDIGQHRAKVEELRQHLLRWGFFTP EEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |