<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2342 2342-30730 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90LM L10F, L33F, T74P I13V, I15V, G16E, L19I, K20T, E35G, M36I, P39T, R41RK, R57K, I62V, L63C, A71V, I72T, I93L  
>2342-30730| codons 4-99
TLWQRPFVTVKVEGQITEALLDTGADDTVFEGINLTGKWKPKIIGGIGGFVKVKQYDQVC
IEICGHKVTGPVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219E K103N, Y181YC, G190GA V108VI K104KR, D121H, K122E, I135V, K166KR, I167IV, D177DE, I178IV, E194ED, T200TA, I202IV, D218E, L228H, V245M  
>2342-30730| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLKKNRSVTILDVGDAYFSVPLHEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTRVLEPFRKQNPEVVICQYVDDLYVASDLDIGQHRAKVEELRQHLLRWGFFTP
EEKHQKEPPFHWMGYELHPDKWTVQPIMLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006