Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2407 | 2407-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L33F, K43T | L10I, E34Q, E35D, M36I, K55KR, R57K, D60E, I62V, L63P, A71V, V77I, I93L |
| >2407-30821| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFQDINLPGRWTPKIIGGVGGFVRVKQYEQVP IEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | V75VA, K219E | K103N, Y181YC | T39A, E40F, K43E, W88C, K102R, V118I, K122E, G196E, T200A, Q207QR, H208Y, R211KQ, L228H |
| >2407-30821| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSTRWRKLADFRELNKRTQDFCEVQLGIPHP AGLKRNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIEQHRAKIEELRRYLWQWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |