Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2225 | 2225-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, M184V, T215F | T69G, K219E | Y188L | K43N, D67X, V90I, K122E, I135V, S162AD, D177E, T200R, R211K |
| >2225-30820| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKXSGRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPEIVIYQYVDDLLVGSDLEIGQHRRKIEELRQHLLKWGFFTP DEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A | L24I, L33F | L10I, F53Y, K55KR, L63P, A71V, V77I |
| >2225-30820| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIVGIGGYTRVRQYDQIP IEICGHKVIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |