Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2223 | 2223-30805 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, V75M, M184V, T215F | D67G, K219Q | K101E, V106M, Y181V, G190A | K64R, T69N, V118I, K122E, I135V, T139A, Q174N, I202IV, F214L, L228H, Q242E, V245K |
| >2223-30805| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIRKKGSNRWRKIMDFRELNKRTQDFWEVQLGIPHP AGLEKKKSMTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKNNPDIVIVQYVDDLYVASDLEIGQHRTKVEELRQHLLRWGLFTP DQKHQKEPPFHWMGYELHPDKWTVEPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L10F, L24I, L33F | I15IV, G16A, K20M, M36I, R41K, K55R, L63P, A71V, T74S, T91A, I93L |
| >2223-30805| codons 4-99 TLWQRPFVTIKVAGQLMEALIDTGADDTVFEEINLPGKWKPKIIGGIGGFVRVRQYDQIP IEICGHKVIGSVLVGPTPANVIGRNLLAQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |