<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2223 2223-30805 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L74I, M184V, T215F D67G, V75M, K219Q K101E, V106M, Y181V, G190A   K64R, T69N, V118I, K122E, I135V, T139A, Q174N, I202IV, F214L, L228H, V245K Q242E
>2223-30805| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIRKKGSNRWRKIMDFRELNKRTQDFWEVQLGIPHP
AGLEKKKSMTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKNNPDIVIVQYVDDLYVASDLEIGQHRTKVEELRQHLLRWGLFTP
DQKHQKEPPFHWMGYELHPDKWTVEPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V L10F, L24I, L33F I15IV, G16A, K20M, M36I, R41K, K55R, L63P, A71V, T74S, T91A, I93L  
>2223-30805| codons 4-99
TLWQRPFVTIKVAGQLMEALIDTGADDTVFEEINLPGKWKPKIIGGIGGFVRVRQYDQIP
IEICGHKVIGSVLVGPTPANVIGRNLLAQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006