Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1599 | 1599-30624 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V | F53L, Q58QE | L10I, I13V, G16A, K20R, E35D, M36I, N37D, Q61K, L63P, A71V, I72E |
| >1599-30624| codons 4-99 TLWQRPIVTVKIAGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGLVKVREYDKIP IEICGHKVEGTVLVGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, M184V, T215F | D67G, K219E | Y181C | V108VI | E44ED, V60I, S68G, L109LI, D123E, I135T, S162SN, Q174R, Q207E, R211K, D218E, L228LH |
| >1599-30624| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKGGTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTIIDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKRNPDIVICQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |