Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2258 | 2258-30721 | U.S. | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10F | I13V, G16E, K20I, E35D, M36I, P39S, R41K, I62V, L63C, I64V | K45A, R57KT |
| >2258-30721| codons 4-99 TLWQRPFVTVKIEGQLIEALLDTGADDTVLEDINLSGKWKPAMIGGIGGFVKVTQYDQVC VEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_VG, L74V, M184V | D67E | Y181CF, Y188L | K101H | V60I, D121Y, K122E, T139K, D177E, I178L, V189I, T200AV, Q207E, R211K, H221Y, T240A, V245K |
| >2258-30721| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKESSKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIFQYVDDLLIGSDLEIGQHRVKIEELREHLLKWGFTTP DKKYQKEPPFLWMGYELHPDKWAVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |