Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1666 | 1666-30429 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67G, K219N | Y181C, G190A | E44D, K49Q, S68G, V90I, K122P, D123DE, I178IM, V179VI, H208HY |
| >1666-30429| codons 38-247 CTELEKDGKISQIGPENPYNTPVFAIKKKGGTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDPEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMIICQYMDDLYVASDLEIGQHRTKIEELRQYLWRWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I50V, I54V, V82A | L10F, V11I, L33F, F53FL, G73S, L89V | G16A, R41RK, K55R, R57K, D60E, L63P, G68GE, K70R, A71V |
| >1666-30429| codons 4-99 TLWQRPFITIKIAGQLKEALLDTGADDTVFEEMNLPGKWKPKLIVGVGGLVRVKQYEQIP IEICEHRVISTVLVGPTPANIIGRNVLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |