Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2498 | 2498-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, I62V, L63P, I66IV, V77I, I93L |
| >2498-30822| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYDQVP IEVCGHKAISTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LV, T215F | K219H | K103KN, Y181YC | E44D, T69TN, D121H, K122E, Q174K, D177E, I178M, H208Y, R211K, D218E, V245M |
| >2498-30822| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPEMVICQYMDDLYVGSDLEIGQHRTKIEELRQYLLKWGFFTP EHKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |