Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1594 | 1594-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, I84V, L90M | L10F, Q58E | K20R, E35D, M36I, N37S, R41RK, I62V, L63T, A71V, I72T, T74S, L89M, Q92K, I93L |
| >1594-30822| codons 4-99 TLWQRPFVTIKIGGQLREALLDTGADDTVLEDISLPGKWKPKIIGGIGGFVKVREYDQVT IEICGHKVTGSVLVGPTPVNVIGRNMMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, V75M, T215Y | K219N | K103N, Y181YC, G190A | E40F, K43E, V118I, K122KE, D123EK, I202V, L210S, V245T | I159IL |
| >1594-30822| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKIMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEKFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP ALFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKVEELRQHLSRWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |