Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2156 | 2156-30815 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | K103N, Y181C | V108I | T39A, K43Q, E44D, V118I, K122E, I135V, S162C, D177N, R211K, D218E, L228H |
| >2156-30815| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPNIVICQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP ENKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L24I, L33F, K43T, G73CS | L10I, I13V, K20KR, E35D, M36I, N37D, R41RK, L63P, I64IV, I72IR |
| >2156-30815| codons 4-99 TLWQRPIVTVKIGGQLREALIDTGADDTVFEDIDLPGKWTPKIIGGIGGFVKVRQYDQIP VEICGHKARSTVLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |