Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1786 | 1786-30506 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82T, L90M | L89V | L10R, I13V, L19T, K20M, E35E_E, M36I, L63P, A71I |
| >1786-30506| codons 4-99 TLWQRPRVTVKIGGQTMEALLDTGADDTILEEINLPGRWKPKIVGGIGGFMKVRQYDQIP IEICGHKIIGTVLVGPTPTNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219N | L100LI, K103KN | T39A, K122E, I135RT, S162C, K173KR, T200A, H208HY, R211K, L228H |
| >1786-30506| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRRQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |