<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1722 1722-30414 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y A62AV, V75VAIT, K219R G190A   T39A, K43Q, E44D, K49R, A98S, V111I, V118I, K122E, I135T, A158S, E169D, Q174K, I178M, V179VI, G196E, T200A, E203K, Q207D, H208Y, R211K, K223EQ  
>1722-30414| codons 38-247
CAELEQDGKISRIGPENPYNTPVFVIKKKNSDKWRKVTDFRELNKRTQDFWEVQLGIPHP
SGLKKKKSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
SIFQSSMTKILDPFRKKNPDMIIYQYVDDLYVASDLEIEQHRAKIKELRDYLWKWGFYTP
DRKHQQEPPFLWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54M, I84V, L90M L10F, G73C R8*, N37D, I62V, L63P, A71T, I72T, V77VI, I93L  
>1722-30414| codons 4-99
TLWQ*PFVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIVGGIGGFMKVRQYDQVP
IEICGHKTTCTVLIGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006