Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1722 | 1722-30414 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F, G73C | R8*, N37D, I62V, L63P, A71T, I72T, V77VI, I93L |
| >1722-30414| codons 4-99 TLWQ*PFVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIVGGIGGFMKVRQYDQVP IEICGHKTTCTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, V75VAIT, M184V, L210W, T215Y | A62AV, K219R | G190A | T39A, K43Q, E44D, K49R, A98S, V111I, V118I, K122E, I135T, A158S, E169D, Q174K, I178M, V179VI, G196E, T200A, E203K, Q207D, H208Y, R211K, K223EQ |
| >1722-30414| codons 38-247 CAELEQDGKISRIGPENPYNTPVFVIKKKNSDKWRKVTDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP SIFQSSMTKILDPFRKKNPDMIIYQYVDDLYVASDLEIEQHRAKIKELRDYLWKWGFYTP DRKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |