Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2150 | 2150-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54LV, L76V, V82A | L33F | L10I, I13V, G16E, M36IV, K43KQ, K55R, D60E, Q61D, L63T, C67Y, I72T, T74TS, L89M | P39P_EK |
| >2150-30818| codons 4-99 TLWQRPIVTVKIEGQLKEALLDTGADDTVFEEVNLPGRWQPKIIGGIGGFVRVRQYEDIT IEIYGHKATGSVVVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, M184V, L210W, T215FY | T69G, K219E | Y181V | V108I | T39A, E40D, V60I, K66X, D67X, K102E, V118VI, K122E, I135T, T139TA, S162CY, V179I, T200TA, D218E, H221HY, L228H, Q242H |
| >2150-30818| codons 38-247 CADLEKEGKISKIGPENPYNTPIFAIKKXQSGRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKEKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNEAPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIIIVQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTP EEKYQKEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |