Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1808 | CA7442 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 143 |
| 2 | DDI | 169 |
| 3 | D4T+3TC+IDV | 61 |
| 4 | 3TC+AZT+DDI+IDV | 8 |
| 5 | AZT+3TC+NVP+NFV | 72 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73S | L10I, I15V, K20I, M36I, R41K, I62V, L63P, I72L, I93L |
| >CA7442| codons 1-99 PQITLWQRPIVTIKVGGQLIEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGHKALSTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V | D67G | E6ED, K20R, E44D, S68G, V118VI, I135V, S162C, Q174QH, N175NY | P140PQ |
| >CA7443| codons 1-193 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSVNNETQGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKHYPDIVI YQYVDDLYVGSDL |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |