Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1572 | 1572-30508 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I47V, I54M, I84V, L90M | L33I | L10I, I13V, E35D, M36L, N37D, K55R, R57K, I62V, L63P, I66F, A71V |
| >1572-30508| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVIEDLDLPGRWKPKLVGGIGGFMRVKQYDQVP IEFCGHKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, L210W, T215Y | K219N | L100I, K101E, G190A | A98G, F227L | T39TA, K43Q, E44D, R83RS, W88C, V118I, K122E, S134SN, E138A, G196GE, E203K, H208Y, R211K, K223E, L228H |
| >1572-30508| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKSTQDFCEVQLGIPHP GGIEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPNINNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTP DNKHQEEPPLHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |