Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2000 | 2000-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | L10V, I13V, I15V, Q18QH, L19I, K20M, E35D, M36I, I62V, L63P, A71V |
| >2000-30715| codons 4-99 TLWQRPVVTVKVGGHIMEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVRQYDQVP IEICGHKVIGTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K103N | V108I | K43KQ, K122E, I135T, S162SC, T200A, E203D, R206RS, R211K, H235HL |
| >2000-30715| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIDELSQHLLKWGFYTP DKKHQKEPPFLWMGYELLPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |