Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1998 | 1998-30701 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | L10I, I62V, L63P, A71I, I72V, V77I, I93L | D25DH |
| >1998-30701| codons 4-99 TLWQRPIVTIKIGGQLKEALLHTGADDTVLEEMNLPGRWKPKMIVGVGGFAKVRQYDQVP IEICGHKIVGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219Q | K101P, K103N | V60VI, T69TN, K122E, D177E, I178L, G196E, Q207H, R211K, D218E |
| >1998-30701| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLPKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIYQYMDDLYVGSDLEIEQHRTKIEELRHHLLKWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |