Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1561 | 1561-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M, T215F | A62V, V75I, F77L, F116Y, K219E | Y181I | V108I | I50IV, T58N, T69N, V90VI, L100V, V106VL, V111I, V118I, K122E, I135T, I202T, R211K, F214C, H221Y, L228H |
| >1561-30610| codons 38-247 CTEMEKEGKISKVGPENPYNNPVFVIKKKNSNRWRKLIDLRELNKRTQDFWEIQLGIPHP AGVKKKKSLTILDIGDAYYSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDIVIIQYMDDLYVGSDLEIGQHRTKTEELRQHLLKWGCFTP DEKYQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11I, G73S | L10I, T12S, I13M, I15V, L19M, K20I, M36I, K55R, R57K, I62V, L63P, C67F, A71V, I85V |
| >1561-30610| codons 4-99 TLWQRPIISMKVGGQMIEALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVKQYDQVP IEIFGHKVISTVLVGPTPANIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |