Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2175 | 2175-30730 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, K20KLMQ, N37D, R41K, D60E, I62V, L63C, I64V, A71V, V77I, I93L |
| >2175-30730| codons 4-99 TLWQRPIVTIKIGGQLQEALLDTGADDTVLEEMDLPGKWKPKMIGGIGGFVKVRQYEQVC VEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, M184V, T215FV | K219Q | K103KN | T39TA, V60I, T69TN, D121Y, K122E, S162SDGN, D177E, I178M, V179VI, G196GE, T200TA, Q207H, H208HY, R211K, D218DE |
| >2175-30730| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPEMIIYQYVDDLYVGSDLEIEQHRAKIEELRHYLLKWGFVTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |