Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2473 | 2473-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | V11I, L33I, G73GA, L89V | L10I, I13V, K20I, M36I, I62V, L63P, G68GE, H69HR, A71T, I72IT, V82I, I93L |
| >2473-30821| codons 4-99 TLWQRPIITVKIGGQLIEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYDQVP IEICERKTTATVLVGPTPINVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_VG, M184V | A62V, T215I | K103S, G190GA | A98G | K122E, I178IM, T200TA, V245E |
| >2473-30821| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKSKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYVDDLYVASDLEIGQHRAKIEELRQHLLRWGFITP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |