Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1857 | 1857-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V | L33F | L10I, I13V, N37S, I62V, L63A, T74S, V77I, L89M, I93L |
| >1857-30527| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMSLPGRWKPKMIGGIGGFLKVRQYDQVA IEICGHKAIGSVLIGPTPVNVIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_XT, T215Y | D67DE | Y181C | S48T, K101Q, K122KE, I135V, E138EG, I178L, Q207E, R211K, L228R |
| >1857-30527| codons 38-247 CTELEKEGKITKIGPENPYNTPVFAIKKKESTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNGTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVICQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |