Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1853 | 1853-30428 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, L210W, T215Y | K219R | K103KN, Y181YC, G190GA | V108I | K43N, E44D, K101KQ, V118I, K122E, I135T, I195IT, G196K, I202V, H208Y, R211K, H221Y, L228H |
| >1853-30428| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLETKQHRTKVEELRQYLWKWGFYTP DRKYQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L10F, L24I, F53L | I62IV, L63P, T74S, L89M, T91A |
| >1853-30428| codons 4-99 TLWQRPFVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGLVKVRQYDQVP IEICGHKAIGSVLVGPTPVNVIGRNMLAQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |