Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2477 | 2477-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, G73T | K20I, E35D, M36I, N37Q, R57K, L63P, I64V, A71V, I72R, I85V |
| >2477-30821| codons 4-99 TLWQRPFVTIKIGGQLIEALLDTGADDTVLEDIQLPGRWKPKMIGGIGGFVKVKQYDQIP VEICGHKVRTTVLVGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69T_T, K70R, L74LV, M184V, L210W | D67G, T215E, K219Q | Y181C | V108VI | K64N, V111VI, V118VI, K122E, D123DG, I202V, E203K, R211K, F214FL, D218E |
| >2477-30821| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAINKKGSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDIGDAYFSIPLDEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTKVKELRQHLWKWGLETP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |