Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2388 | 2388-30814 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_TT, M184MI, T215Y | G190A | S68T, W88C, K101Q, K103KR, K122KE, I142V, K173KR, R211K, V245T |
| >2388-30814| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDTTKWRKLVDFRELNKRTQDFCEVQLGIPHP AGLQKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRRQNPDIVIYQYIDDLYVASDLEIGQHRTKIEELRQHLLKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, V82A | L33LF, Q58QE | L10I, I13IV, E35D, M36I, R41K, I62V, L63P, A71AT, T74S |
| >2388-30814| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEDINLPGKWKPKMIGGIGGFMKVREYDQVP IEICGHKTIGSVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |