Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2427 | 2427-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46LV, I54V, L76V, V82C | L10F | I15V, N37D, I62V, L63P, I93L |
| >2427-30820| codons 4-99 TLWQRPFVTIKVGGQLKEALLDTGADDTVLEEMDLPGRWKPKVIGGIGGFVKVRQYDQVP IEICGHKAIGTVVVGPTPCNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | A62V, V75I | K49KR, S68G, D123E, I135T, I142V, D177E, T200K, V245E |
| >2427-30820| codons 38-247 CTELEKEGKISRIGPENPYNTPVFVIKKKDGTKWRKLIDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRKKIEELRQHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |