Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2330 | 2330-30811 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I47IV, I54L, I84V, L90M | L10F, L33F, G73GS, L89V | I13V, K14R, K20KT, R41RK, I66IF, A71V, T91TS |
| >2330-30811| codons 4-99 TLWQRPFVTVRIGGQLTEALLDTGADDTIFEEMNLPGKWKPKIVGGIGGFLKVRQYDQIL IEFCGHKVISTVLVGPTPVNVIGRNVMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70KR, L74V, M184V, T215FS | D67DH, K219Q | Y181YFIN, G190CS | V60I, T69TN, K122E, I135T, F214L, D218DE, Q242QL |
| >2330-30811| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKHSNRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVINQYVDDLYVSSDLEIGQHRTKIEELRQHLLRWGLSTP EQKHQKEPPFLWMGYELHPDKWTVLPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |