Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2329 | 2329-30804 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, K43T, G73C | L10I, G16A, I62V, L63P, I64IV, I72IKLQ, V77I, P79N, I93IL |
| >2329-30804| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTIFEEMNLPGRWTPKIVGGIGGFLKVRQYDQVP VEICGHKAQCTVLIGNTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219KR | K43Q, E44D, V111VIM, V118I, K122E, S162D, D177DG, G196E, T200A, H208Y |
| >2329-30804| codons 38-246 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDMGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIEQHRAKIEELRQYLWRWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |