Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2297 | 2297-30812 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | T215I, K219E | K103KN, G190A | V60I, K102N, V106I, K122KE, D123E, K173T, Q174QK, D177DE, T200A | M41MI |
| >2297-30812| codons 38-247 CTEIEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKNNKSITVLDVGDAYFSVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRTKNPEIVIYQYVDDLYVASDLEIGQHRAKIEELRQHLLRWGFITP DEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54AV, V82A, I84V | L10F, L89V | V11L, I13V, L19Q, K20I, M36I, L63P, H69K, K70R, A71T, T74S, T91S |
| >2297-30812| codons 4-99 TLWQRPFLTVKIGGQQIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQIP IEICGKRTIGSVLVGPTPANVIGRNVLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |