Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2207 | 2207-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | K43T, F53FL | L10I, T12D, I15V, K20R, M36I, D60E, I62IV, L63P, A71V, I93L | L5H |
| >2207-30715| codons 4-99 THWQRPIVDIKVGGQLREALLDTGADDTVLEEINLPGRWTPKMIGGIGGLVKVRQYEQVP IEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | F77FL | K43E, E44A, E53EQ, V118I, K122E, I135K, T139TS, I142IMT, K173Q, G196E, R211K, V245E |
| >2207-30715| codons 38-247 CTELEEAGKISKIGPQNPYNTPVFAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSKNNESPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRQQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |