Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1538 | 1538-30616 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | L10F, L33F, K43T | I13V, E34Q, N37E, L63A, A71V, V77I |
| >1538-30616| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTIFQEMELPGRWTPKIVGGIGGFMKVRQYDQIA IEICGHKVIGTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215F | K219W | K101KDEN, Y181C, G190A | V108I | K43KN, K65K_N, K103KR, T139TI, S162C, V189I, H208Y, R211K, D218E |
| >1538-30616| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLNKRKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSINNEIPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVICQYMDDLYIASDLEIGQHRTKIEELRQYLLKWGFFTP EWKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |