Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1208 | 1208-30507 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33I, K43T, F53L | L10I, G16E, K20R, E35D, M36I, N37NI, K55R, R57K, D60E, I62IV, L63T, I64V, A71V, I85V, Q92K, I93L |
| >1208-30507| codons 4-99 TLWQRPIVTIKIEGQLREALLDTGADDTVIEDIILPGRWTPKLIGGIGGLVRVKQYEQVT VEICGHKVIGTVLVGPTPANIVGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | V75M | K103N | A98G, V108VI | T39D, K82R, K122E, I135L, K173N, Q174K, D192N, Q207E |
| >1208-30507| codons 38-247 CDELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVMDFRELNRRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRNKNPDIVIYQYVDDLYVGSNLEIGQHRTKIEELREHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |