Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1524 | 1524-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10FI, V11I, G73S, L89V | I15V, K20M, M36I, I62V, L63P, A71T, I72L, I85V |
| >1524-30820| codons 4-99 TLWQRPIITIKVGGQLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYDQVP IEICGHKTLSTVLVGPTPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, L210W, T215F | K219Q | K103N, Y181C | T39A, E44D, A98S, K122E, I135T, S162D, K166R, D177DN, G196E, T200A, D218E, K223Q, L228H, Q242H |
| >1524-30820| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDSMTRILEPFRKQNPNIVICQYMDDLYVGSDLEIEQHRAKIEELRQHLWRWGFFTP EQKHQQEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |