<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1524 1524-30820 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10FI, V11I, G73S, L89V I15V, K20M, M36I, I62V, L63P, A71T, I72L, I85V  
>1524-30820| codons 4-99
TLWQRPIITIKVGGQLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYDQVP
IEICGHKTLSTVLVGPTPVNVVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74V, L210W, T215F K219Q K103N, Y181C   T39A, E44D, A98S, K122E, I135T, S162D, K166R, D177DN, G196E, T200A, D218E, K223Q, L228H, Q242H  
>1524-30820| codons 38-247
CAELEKDGKISKIGPENPYNTPVFAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHP
SGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQDSMTRILEPFRKQNPNIVICQYMDDLYVGSDLEIEQHRAKIEELRQHLWRWGFFTP
EQKHQQEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006