Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1199 | 1199-30225 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48L, I50V, I54T, V82A | L10I, I15V, G16A, N37S, L63P, A71T, V77I, I85V, Q92K |
| >1199-30225| codons 4-99 TLWQRPIVTIKVAGQLKEALLDTGADDTVLEEMSLPGRWKPKMILGVGGFTKVRQYDQIP IEICGHKTIGTVLIGPTPANIVGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SS, M184V, T215Y | A62V, V75VL | K103N | V108I | K122E, D123N, I135T, E138Q, K173R, Q207E, L210S, R211K | I159IK |
| >1199-30225| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSSKWRKLLDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDENFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSP AKFQSSMTKILEPFRRQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELREHLSKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |