Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1685 | 1685-30327 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | L10FI, L33F, Q58E | T12S, I13V, G16GA, L19I, K20R, M36L, L63P, I64V, I66V, H69R, Q92K, I93L, C95F |
| >1685-30327| codons 4-99 TLWQRPIVSVKIAGQIREALLDTGADDTVFEELNLPGRWKPKIIGGIGGFVKVREYDQIP VEVCGRKAIGTVLVGPTPANVIGRNLMTKLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215Y | K219N | K103N, Y181YC, G190GA | V108VI | E44D, K64KR, K102R, V118I, D123E, I135T, D177E, I178M, L210S, V245T |
| >1685-30327| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIRKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRNKSVTILDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVICQYVDDLYVASDLEIGQHRTKIEELRQHLSRWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |