Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2384 | 2384-30815 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L10F, N83D, N88D | I13V, G16A, A22V, E34Q, N37ND, R57K, L63P, A71V, T91A |
| >2384-30815| codons 4-99 TLWQRPFVTVKIAGQLKEVLLDTGADDTVLQEMDLPGRWKPKIIGGIGGFIKVKQYDQIP IEICGHKVIGTVLVGPTPVDVIGRDLLAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K43E, K49R, E53D, V118I, K122E, S162H, H208Y, R211K |
| >2384-30815| codons 38-247 CTELEEEGKISRIGPDNPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQHSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |